nasopharyngeal carcinoma prognostic factors
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nasopharyngeal carcinoma prognostic factors  등록일  2021-01-25

The authors have no conflicts of interest to disclose. Int J Radiat Oncol Biol Phys 2001;50:717-26. Thus, the main purpose of our study was to investigate the metastasis patterns of different histological types of NPC and to clarify the prognostic characteristics of metastases at different sites. This was a single-center retrospective analysis of patients in China from January 2010 to December 2015. To retrospectively analyze the prognosis of patients with nasopharyngeal carcinoma (NPC) initially presenting with liver metastasis, in order to identify independent prognostic factors to facilitate management of treatment. Nasopharyngeal carcinoma Prognostic factors Overall survival Salvage intensity-modulated radiotherapy Meta-analysis ABSTRACT Local recurrence remains a major cause of therapeutic failure in patients with nasopharyngeal carcinoma (NPC) and the effective treatment of recurrent NPC (r-NPC) is still a challenge. Background: The prognostic values of staging parameters require continual re‑assessment amid changes in diag‑ nostic and therapeutic methods. 2020;99:49(e23173). KEYWORDS: nasopharyngeal carcinoma, prognostic factors, tumor angiogenesis, c-erbB2, immunohistochemistry. 651 Dongfeng Road East, 510060 Guangzhou, China (e-mail: guoxiang@sysucc.org.cn) and … Clinical stage is the most important prognostic factor: 5 year disease specific survival is 98% for stage I, 95% for stage II, 86% for stage III and 73% for stage IV Other adverse prognostic factors include older age, male gender, large tumor volume and cranial nerve palsy Case reports. Some people with several risk factors never develop cancer, while others with no known risk factors do. In contrast to other squamous cell carcinoma of the head and neck, nasopharyngeal carcinoma(NPC) is characterized by a high tendency for metastatic dissemination [3].Thirty to 60% of patients with locally advanced disease will develop distant metastasis within five years of diagnosis, while 5 to 8% present with distant metastasis at diagnosis , . Despite the advances in radiation therapy techniques, some patients relapse after treatment. (A) We applied NMF (k = 5 factors or expression patterns) to analyze the gene expression profiles of nasopharyngeal carcinoma (NPC) samples in the training cohort (n = 113). SUBJECTS AND METHOD: We retrospectively reviewed medical records of 87 patients who were treated for nasopharyngeal carcinoma from 1994 … Nasopharyngeal cancer is a type of head and neck cancer that occurs when cells in the nasopharynx, the upper part of the throat behind the nose and near the base of the skull, grow out of control.. Nasopharyngeal carcinoma (NPC) exhibits a distinctive racial and geographic distribution. Radiation therapy or concurrent chemoradiation therapy is mainstay for treatment of nasopharyngeal carcinoma. The high chemoresponsiveness of NPC is … Nasopharyngeal carcinoma (NPC) has distinct characteristics from other head and neck cancers and accounts for only 0.7% of all cancer cases diagnosed in 2018 globally. American Journal of Rhinology & Allergy 0 10.1177/1945892420964054 Download Citation. demonstrated that the most significant prognostic factors in nasopharyngeal carcinoma were patient age, stage of the primary tumor, presence of cervical lymphadenopathy and certain technical factors of irradiation. We investigated the clinical characteristics, prognostic factors, and post-recurrence prognostic factors of early- and late-recurrence patients for nasopharyngeal carcinoma (NPC) after definitive intensity-modulated radiation therapy (IMRT). Prognostic factors of nasopharyngeal carcinoma (NPC) have been one of the most important research foci, and a large number of investigations in this area have been performed and published. N asophatyngeal carcinoma (NPC) is unique from other head and neck cancers because of its epidemiology, association with the Epstein- Barr virus, and biologic behavior.’ NPC occurs in a younger population, grows rapidly in the local and regional areas, and is highly metastatic. However, no information is available about the prognostic factors. 2004 Jul 1;22 (13):2643 ... DMR and LRFR were not reduced with AC (P =.34 and.15, respectively). This study aimed to establish an effective prognostic nomogram for patients with NPC with distant metastases using easily determined factors.Methods: The nomogram was based on a retrospective study of 103 patients with metastatic NPC at the First Affiliated Hospital of Xiamen … KW - Radiotherapy Tests that examine the nose and throat are used to detect (find) and diagnose nasopharyngeal cancer. METHODS: Between March 3 rd and April 5 th , 2020, we conducted a retrospective study on a cohort of COVID-19 patients (mild or severe disease) who were hospitalized after presenting to the emergency department (ED) and had at least one positive nasopharyngeal swab … Here, we used features of MR images as prognostic factors in patients with advanced nasopharyngeal carcino-ma. Cox model showed CRT to be a favorable prognostic factor for OS (hazard ratio, 0.42; P =.009). Many studies have reported varied significant prognostic factors affect the survival of NPC patients. The nomograms … Radiation therapy or concurrent chemoradiation therapy is mainstay for treatment of nasopharyngeal carcinoma. Hence, this current study aimed to identify the prognostic factors of NPC patients registered in a tertiary referral hospital. Correspondence to: Xing Lv, PhD, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, No. Crossref. 1,2 More than 70% of new NPC cases were reported in East and Southeast Asia. The exact cause of nasopharyngeal cancer is unknown, but a number of factors can increase your risk of developing the condition. Radiomics-based prognostic nomograms were devel-oped based on a training cohort (n ¼ 88) using machine learning methods. Certain factors affect prognosis (chance of recovery) and treatment options. PDF | Introduction Nasopharyngeal carcinoma has the highest metastatic potential of all head and neck cancers. , based on 305 patients with nasopharyngeal carcinoma treated with IMRT, showed that the T stage did not affect the LC and OS rates, whereas the N stage was an independent prognostic factor with an impact on OS. Extended-field radiotherapy for patients with nasopharyngeal carcinoma might contribute to improving their cure-rate, and precise radiation planning is warranted to avoid the late complications such as hearing loss. The objective of this study was to identify factors with an influence on outcome in patients treated in Hospital Kuala Lumpur. Patients were enrolled from the SEER program from 2010 to 2016. … 1 There were approximately 42,100 new cases of NPC in China in 2013, accounting for 1.14% of all new cancer cases in China. Whether you or someone you love has cancer, knowing what to expect can help you cope. Nasopharyngeal cancer is a disease in which malignant (cancer) cells form in the tissues of the nasopharynx. Most nasopharyngeal cancers are nasopharyngeal carcinoma.There are three types of nasopharyngeal cancer: . We evaluated clinical characteristics and treatment outcomes of nasopharyngeal carcinoma and assessed prognostic factors related to survival. The prognostic factor analysis of Han et al. A risk factor is anything that increases a person’s chance of developing cancer. Cheng SH, Yen KL, Jian JJ, et al. NPC differs significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. This study aimed to identify the prognostic factors and failure patterns of non‑meta‑ static nasopharyngeal carcinoma (NPC) in the intensity‑modulated radiotherapy (IMRT) era. We evaluated clinical characteristics and treatment outcomes of nasopharyngeal carcinoma and assessed prognostic factors related to survival. The nasopharynx is the upper part of the pharynx (throat) behind the nose. 651 Dongfeng Road East, 510060 Guangzhou, China (e-mail: lvxing@sysucc.org.cn) and Xiang Guo, PhD, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, No. 3 The primary … BACKGROUND: Nasopharyngeal carcinoma is the third most common cancer among men in Peninsular Malaysia. KW - Nasopharyngeal cancer. New prognostic factors in nasopharyngeal carcinoma: Tumor angiogenesis and C ... Jin-Ching Lin, Prognostic Factors in Nasopharyngeal Cancer, Nasopharyngeal Cancer, 10.1007/978-3-540-92810-2_9, (95-136), (2010). Medicine. Nasopharyngeal carcinoma (NPC), or nasopharynx cancer, is the most common cancer originating in the nasopharynx, most commonly in the postero-lateral nasopharynx or pharyngeal recess (fossa of Rosenmüller), accounting for 50% of cases.NPC occurs in children and adults. Although risk factors often influence the development of cancer, most do not directly cause cancer. Background: Patients with metastatic nasopharyngeal carcinoma (NPC) have heterogeneous survival outcomes. Wanpeng Li, MD, Hanyu Lu, MD, Huan Wang, MD, Huankang Zhang, MD, Xicai Sun, MD, Li Hu, MD, Weidong Zhao, MD, Yurong Gu, MD, Houyong Li, MD, and Dehui Wang, MD. Long term complications and prognostic factors in locally advanced nasopharyngeal carcinoma treated with docetaxel, cisplatin, 5-fluorouracil induction chemotherapy followed by concurrent chemoradiotherapy: A retrospective cohort study. Specifically, the later the N stage is, the worse the prognosis is. The extent of local invasion, regional lymphatic spread, and distant metastasis, as reflected by the TNM staging, are the most important prognostic factors in NPC. In addition, virus infection has also been reported as a prognostic factor for survival outcomes for head and neck cancers. In the coming era of cancer immunotherapy, prognostic factors for LA-NPC need to be further defined using immune-relevant … KW - Prognostic factor. Locally advanced nasopharyngeal carcinoma (LA-NPC) is a relatively rare disease in the west but more common in East Asia and areas of the Middle East like Saudi Arabia. Methods: We retrospectively reviewed the medical records of 419 patients with newly diagnosed, nondisseminated, and biopsy proven NPC. Currently, the features and prognosis of nasopharyngeal carcinoma (NPC) with distant metastases are still rarely reported. From basic information about cancer and its causes to in-depth information on specific cancer types – including risk factors, early detection, diagnosis, and treatment options – you’ll find it here. Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma: a factorial study J Clin Oncol. Salvage Endoscopic Nasopharyngectomy in Recurrent Nasopharyngeal Carcinoma: Prognostic Factors and Treatment Outcomes. Prognostic factors and long‐term outcomes of nasopharyngeal carcinoma in children and adolescents ... Nasopharyngeal carcinoma (NPC) is a rare malignancy in children and adolescents, and the optimal treatment modality in youths has not been established. Analyzing the prognostic factors for nasopharyngeal carcinoma, Perez et al. Examining prognostic factors and patterns of failure in nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy: impact on future clinical trials. The prognostic impact of measuring viral load on nasopharyngeal swab specimens (by RT-PCR) is yet to be elucidated. Background: The purpose of this analysis was to create a prognostic score model for newly diagnosed nasopharyngeal carcinoma (NPC) which has not been created before. Conclusion: An improvement in OS with CRT was observed but did not achieve statistical significance. 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